All Roman GN4 fonts to use the Unicode font layout, independently whether they are the real Unicode fonts or not. Symbol fonts continue to use Symbol or Dingbats font layout.
Important: you can store the full set of Unicode characters in the GN4 database (and this includes also the case when you want to store characters that belong to more than one codepage), as the GN4 database is by default in the Unicode format.
See also paragraph about Unicode font layout in Font layouts.