If Edit and Continue doesn't work:
•Make sure the Visual Studio hit a breakpoint: only while the debugger is waiting on a breakpoint, you can edit the code. If the breakpoint appears as hollow, make sure that before starting a debug session you rebuilt the solution in the debug mode at least once.
•Make sure you are compiling for debug mode - in the release mode, the Edit and Continue is not enabled.
•After updating your system with the latest build, you may need first to rebuild your solution in debug mode, and only then start the debug session, otherwise, the edit and continue may not work.
•Make sure the settings of the GN4 projects in the Visual Studio Express are the default ones. Changes in the Advanced Compiler Settings > Generate Debug Info to anything else than Full will prevent Edit and Continue to work.