You need to reset IIS when:
•After reloading changed configuration files such as GlobalConfig, ServerConfig.
•Setting permissions on Temp folder.
•After changing GN4 schemas.
To reset IIS
Log onto server through RDP and then, in the Administrators Command prompt, issue the command iisreset /stop and then iisreset /start.
Note
Generally speaking, the users logged to GN4 client applications or browser should be able to continue to work without logging out and back in, even after a IISRESET or a recycle of the Application Pool.
However, it's a good practice to perform IISreset only when users are not logged in.